Pharmaceuticals

Harnessing Machine Learning to Transform Sales Forecasting in Rare Disease

Explore how we helped transform manual sales forecasting into a scalable, AI-driven workbench with 90-99% accuracy

Read more

Pharmaceuticals

Harnessing Machine Learning to Transform Sales Forecasting in Rare Disease

Explore how we helped transform manual sales forecasting into a scalable, AI-driven workbench with 90-99% accuracy

Read more
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The Situation
How do you modernize territory-level sales forecasting in rare disease when traditional methods are manual, slow, and increasingly unreliable?

That was the challenge we worked on with our partner. While their teams had deep expertise and robust historical data, forecasting was still time-consuming and heavily manual. The upcoming loss of a critical external data source added further urgency, raising the risk of “flying blind” in a competitive market.

The Situation
The Situation
The Situation
How do you modernize territory-level sales forecasting in rare disease when traditional methods are manual, slow, and increasingly unreliable?

That was the challenge we worked on with our partner. While their teams had deep expertise and robust historical data, forecasting was still time-consuming and heavily manual. The upcoming loss of a critical external data source added further urgency, raising the risk of “flying blind” in a competitive market.

The Situation
How do you modernize territory-level sales forecasting in rare disease when traditional methods are manual, slow, and increasingly unreliable?

That was the challenge we worked on with our partner. While their teams had deep expertise and robust historical data, forecasting was still time-consuming and heavily manual. The upcoming loss of a critical external data source added further urgency, raising the risk of “flying blind” in a competitive market.

The Situation

How do you modernize territory-level sales forecasting in rare disease when traditional methods are manual, slow, and increasingly unreliable?

That was the challenge we worked on with our partner. While their teams had deep expertise and robust historical data, forecasting was still time-consuming and heavily manual. The upcoming loss of a critical external data source added further urgency, raising the risk of “flying blind” in a competitive market.

The Situation

How do you modernize territory-level sales forecasting in rare disease when traditional methods are manual, slow, and increasingly unreliable?

That was the challenge we worked on with our partner. While their teams had deep expertise and robust historical data, forecasting was still time-consuming and heavily manual. The upcoming loss of a critical external data source added further urgency, raising the risk of “flying blind” in a competitive market.

From Strategy to Delivery
From Business Questions to Forecasting Models in Four Weeks

In close collaboration with the commercial insights team, we designed and delivered a machine learning forecasting workbench in just four weeks.

The work focused on:

1. Defining high-value forecasting scenarios such as year-end planning and cycle-level forecasts

2. Running agile experiments across brands and markets to identify the most accurate models

3. Auditing and preparing historical sales data in Snowflake for multiple brands, time horizons, and geographies

The Situation
From Business Questions to Forecasting Models in Four Weeks
From Strategy to Delivery
From Business Questions to Forecasting Models in Four Weeks

In close collaboration with the commercial insights team, we designed and delivered a machine learning forecasting workbench in just four weeks.

The work focused on:

1. Defining high-value forecasting scenarios such as year-end planning and cycle-level forecasts

2. Running agile experiments across brands and markets to identify the most accurate models

3. Auditing and preparing historical sales data in Snowflake for multiple brands, time horizons, and geographies

From Strategy to Delivery
From Business Questions to Forecasting Models in Four Weeks

In close collaboration with the commercial insights team, we designed and delivered a machine learning forecasting workbench in just four weeks.

The work focused on:

1. Defining high-value forecasting scenarios such as year-end planning and cycle-level forecasts

2. Running agile experiments across brands and markets to identify the most accurate models

3. Auditing and preparing historical sales data in Snowflake for multiple brands, time horizons, and geographies

From Strategy to Delivery

From Business Questions to Forecasting Models in Four Weeks

In close collaboration with the commercial insights team, we designed and delivered a machine learning forecasting workbench in just four weeks.

The work focused on:

1. Defining high-value forecasting scenarios such as year-end planning and cycle-level forecasts

2. Running agile experiments across brands and markets to identify the most accurate models

3. Auditing and preparing historical sales data in Snowflake for multiple brands, time horizons, and geographies

From Strategy to Delivery

From Business Questions to Forecasting Models in Four Weeks

In close collaboration with the commercial insights team, we designed and delivered a machine learning forecasting workbench in just four weeks.

The work focused on:

1. Defining high-value forecasting scenarios such as year-end planning and cycle-level forecasts

2. Running agile experiments across brands and markets to identify the most accurate models

3. Auditing and preparing historical sales data in Snowflake for multiple brands, time horizons, and geographies

Key numbers

The case in numbers

90-99

Percent accuracy of models was achieved at brand- and territory-level across horizons. In one major market, the model reached 98% accuracy when aggregating 3- and 6-month predictions for two key brands

4

weeks after project start, the workbench was production ready

7

of 10 key markets immediately adopted the workbench, with further roll-out planned throughout 2025

How We Built It
Engineering a Scalable, Self-Service Forecasting Workbench

The solution was an XGBoost-based time series forecasting engine, built in AWS SageMaker with the Darts framework. It included covariates for richer inputs, automated hyperparameter tuning, and built-in data-quality checks.

Deployed as a modular forecasting workbench, the solution allows planners to configure product, territory, and horizon with minimal setup - reducing experiment time from days to hours and creating a scalable foundation for expansion.

How We Built It
How We Built It
How We Built It
Engineering a Scalable, Self-Service Forecasting Workbench

The solution was an XGBoost-based time series forecasting engine, built in AWS SageMaker with the Darts framework. It included covariates for richer inputs, automated hyperparameter tuning, and built-in data-quality checks.

Deployed as a modular forecasting workbench, the solution allows planners to configure product, territory, and horizon with minimal setup - reducing experiment time from days to hours and creating a scalable foundation for expansion.

How We Built It
Engineering a Scalable, Self-Service Forecasting Workbench

The solution was an XGBoost-based time series forecasting engine, built in AWS SageMaker with the Darts framework. It included covariates for richer inputs, automated hyperparameter tuning, and built-in data-quality checks.

Deployed as a modular forecasting workbench, the solution allows planners to configure product, territory, and horizon with minimal setup - reducing experiment time from days to hours and creating a scalable foundation for expansion.

How We Built It

Engineering a Scalable, Self-Service Forecasting Workbench

The solution was an XGBoost-based time series forecasting engine, built in AWS SageMaker with the Darts framework. It included covariates for richer inputs, automated hyperparameter tuning, and built-in data-quality checks.

Deployed as a modular forecasting workbench, the solution allows planners to configure product, territory, and horizon with minimal setup - reducing experiment time from days to hours and creating a scalable foundation for expansion.

How We Built It

Engineering a Scalable, Self-Service Forecasting Workbench

The solution was an XGBoost-based time series forecasting engine, built in AWS SageMaker with the Darts framework. It included covariates for richer inputs, automated hyperparameter tuning, and built-in data-quality checks.

Deployed as a modular forecasting workbench, the solution allows planners to configure product, territory, and horizon with minimal setup - reducing experiment time from days to hours and creating a scalable foundation for expansion.

How We Built It

Engineering a Scalable, Self-Service Forecasting Workbench

How We Built It
The outcome
High Accuracy. Fast Deployment. Immediate Global Impact.

The models achieved 90-99% accuracy at brand- and territory-level across horizons. In one major market, the model reached 98% accuracy when aggregating 3- and 6-month predictions for two key brands.
The workbench was production-ready at the end of the 4-week project and immediately applicable in 7 of 10 key markets, with further roll-out planned throughout 2025.

The outcome
High Accuracy. Fast Deployment. Immediate Global Impact.

The models achieved 90-99% accuracy at brand- and territory-level across horizons. In one major market, the model reached 98% accuracy when aggregating 3- and 6-month predictions for two key brands.
The workbench was production-ready at the end of the 4-week project and immediately applicable in 7 of 10 key markets, with further roll-out planned throughout 2025.

The outcome
High Accuracy. Fast Deployment. Immediate Global Impact.

The models achieved 90-99% accuracy at brand- and territory-level across horizons. In one major market, the model reached 98% accuracy when aggregating 3- and 6-month predictions for two key brands.
The workbench was production-ready at the end of the 4-week project and immediately applicable in 7 of 10 key markets, with further roll-out planned throughout 2025.

The outcome

High Accuracy. Fast Deployment. Immediate Global Impact.

The models achieved 90-99% accuracy at brand- and territory-level across horizons. In one major market, the model reached 98% accuracy when aggregating 3- and 6-month predictions for two key brands.
The workbench was production-ready at the end of the 4-week project and immediately applicable in 7 of 10 key markets, with further roll-out planned throughout 2025.

The outcome

High Accuracy. Fast Deployment. Immediate Global Impact.

The models achieved 90-99% accuracy at brand- and territory-level across horizons. In one major market, the model reached 98% accuracy when aggregating 3- and 6-month predictions for two key brands.
The workbench was production-ready at the end of the 4-week project and immediately applicable in 7 of 10 key markets, with further roll-out planned throughout 2025.

High Accuracy. Fast Deployment. Immediate Global Impact.

The outcome
The Impact
Laying the Foundation for the Next Wave of Commercial AI

By embedding ML-driven forecasts into its planning rhythm, our partner freed up significant capacity to focus on insights rather than manual forecasting. The forecasts now directly support commercial decision-making, S&OP, and financial planning - while also laying the groundwork for future AI use cases such as sales uplift modelling, price-volume simulations, and next-best-action recommendations.

Crucially, this shift ensures our partner can continue to plan proactively and deliver life-critical treatments to rare disease patients without disruption.

The Impact
Laying the Foundation for the Next Wave of Commercial AI

By embedding ML-driven forecasts into its planning rhythm, our partner freed up significant capacity to focus on insights rather than manual forecasting. The forecasts now directly support commercial decision-making, S&OP, and financial planning - while also laying the groundwork for future AI use cases such as sales uplift modelling, price-volume simulations, and next-best-action recommendations.

Crucially, this shift ensures our partner can continue to plan proactively and deliver life-critical treatments to rare disease patients without disruption.

The Impact
Laying the Foundation for the Next Wave of Commercial AI

By embedding ML-driven forecasts into its planning rhythm, our partner freed up significant capacity to focus on insights rather than manual forecasting. The forecasts now directly support commercial decision-making, S&OP, and financial planning - while also laying the groundwork for future AI use cases such as sales uplift modelling, price-volume simulations, and next-best-action recommendations.

Crucially, this shift ensures our partner can continue to plan proactively and deliver life-critical treatments to rare disease patients without disruption.

The Impact

Laying the Foundation for the Next Wave of Commercial AI

By embedding ML-driven forecasts into its planning rhythm, our partner freed up significant capacity to focus on insights rather than manual forecasting. The forecasts now directly support commercial decision-making, S&OP, and financial planning - while also laying the groundwork for future AI use cases such as sales uplift modelling, price-volume simulations, and next-best-action recommendations.

Crucially, this shift ensures our partner can continue to plan proactively and deliver life-critical treatments to rare disease patients without disruption.

The Impact

Laying the Foundation for the Next Wave of Commercial AI

By embedding ML-driven forecasts into its planning rhythm, our partner freed up significant capacity to focus on insights rather than manual forecasting. The forecasts now directly support commercial decision-making, S&OP, and financial planning - while also laying the groundwork for future AI use cases such as sales uplift modelling, price-volume simulations, and next-best-action recommendations.

Crucially, this shift ensures our partner can continue to plan proactively and deliver life-critical treatments to rare disease patients without disruption.

Laying the Foundation for the Next Wave of Commercial AI

The Impact
Reflections

What we learned

0
Speed creates momentum

Delivering a production-ready prototype in four weeks accelerated adoption.

0
Accuracy builds trust

Demonstrating 90-99% accuracy made the value clear across markets.

0
Scalability drives impact

A modular setup enabled rapid roll-out across brands and geographies.

0
AI builds resilience

Reducing reliance on external data safeguarded continuity in a sensitive therapeutic area.

Want to build something similar? Let's talk.

Feel free to reach out to one of our team members with expertise in this area. Whether you're facing a similar challenge or exploring where to start, we’re ready to help you turn ideas into action.

Senior Consultant - Intellishore CH
Jonatan Edry

Senior Consultant - Intellishore CH
Jonatan Edry
Jonatan Edry
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Manager - Intellishore CH
Anibal Granada-Gonzalez

Manager - Intellishore CH
Anibal Granada-Gonzalez
Anibal Granada-Gonzalez
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Senior Consultant - Intellishore CH
Alexander Søe

Senior Consultant - Intellishore CH
Alexander Søe
Alexander Søe
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Managing Director, Intellishore CH
Mikkel Møller Andersen

Managing Director, Intellishore CH
Mikkel Møller Andersen
Mikkel Møller Andersen
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Consultant - Intellishore CH
Nikoline Balle

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